Supplement Stack — Amazon UK Reference Table

Phase 1 Foundation Weeks 1–4 · Introduce one at a time with 1-week gap (MCAS protocol)

#	Supplement	Recommended Product	Dose / Timing	Supply	Price	Per Day	Why This Pick · Notes	Buy
1	Magnesium Glycinate Triple complex (glycinate + malate + citrate) hEDSPOTSMCASMigraine	Unicorn Brands Magnesium Glycinate 3-in-1 Complex · 1800mg · 384mg elemental · 90 vegan caps · UK Made	2 caps/day ~384mg elem. Evening, with water	3 months	~£10	~11p	Tri-form provides glycinate (sleep/brain), malate (Krebs cycle/energy) and citrate (bowel tolerance). UK-made, 384mg elemental hits therapeutic range. Exceptional value — best-reviewed UK magnesium complex at this price point.	Amazon UK
2	Vitamin D3 + K2 MK-7 4000 IU D3 · 100mcg K2 hEDSMCASPOTSMigraine	Unicorn Brands Vitamin D3 4000iu + K2 MK7 100μg · 365 tablets · 1-year supply · UK Made · Vegetarian	1 tablet/day 4000 IU D3 With fatty meal	12 months	~£12	~3p	Best-value D3/K2 combo on Amazon UK — 14,000+ reviews. K2 as true MK-7 (menaquinone-7), essential to prevent arterial/soft tissue calcification in hypermobile individuals. D3 at 4000 IU is appropriate for hEDS/MCAS where deficiency is near-universal.	Amazon UK

Phase 2 Mitochondrial Energy Chain Weeks 4–8 · Allow 8–12 weeks to assess full migraine prevention effect

#	Supplement	Recommended Product	Dose / Timing	Supply	Price	Per Day	Why This Pick · Notes	Buy
3	CoQ10 Ubiquinol Active reduced form · 100mg softgels MigrainehEDSPOTS	Solgar Ubiquinol Ubiquinol 100mg Softgels (KanekaQH®) · Pack of 50 · In olive oil carrier for absorption	2 softgels/day = 200mg With largest meal	25 days (buy 2)	~£30	~60p	Uses KanekaQH® — the gold standard patented ubiquinol. Solgar's olive oil carrier maximises fat-soluble absorption. Ubiquinol (not ubiquinone) is the pre-reduced form — significantly better absorbed, especially for over-40s or those with mitochondrial dysfunction. Pricier but justified by bioavailability. 💡 Budget alternative: Igennus VESIsorb Ubiquinol 100mg (~£25/90 caps) offers water-soluble delivery at lower per-cap cost.	Amazon UK
4	Riboflavin B2 400mg — therapeutic migraine dose MigrainehEDS	Nutricost / Living Manna Vitamin B2 Riboflavin 400mg · 120 vegan capsules · Non-GMO · GMP certified	1 cap/day 400mg Morning with food	4 months	~£14	~12p	400mg is the NICE-recommended and WHO Grade A evidence dose for migraine prophylaxis — not achievable from diet. Pure riboflavin, not the phosphate form, is sufficient at this dose. Urine will turn bright yellow — harmless and confirms absorption. Allow 3 months to assess migraine frequency reduction.	Amazon UK

Phase 3 Fascia, Mast Cell Stabilisation & Collagen Synthesis Weeks 8–12 · Directly targets the CHA axis, interstitium and MCAS loop

#	Supplement	Recommended Product	Dose / Timing	Supply	Price	Per Day	Why This Pick · Notes	Buy
5	Quercetin Pure 500mg · mast cell stabiliser MCASMigrainehEDSPOTS	New Leaf / VitaBright Quercetin 500mg · 180 vegan capsules · 6-month supply · UK Made · Non-GMO	1–2 caps/day 500–1000mg Before meals	3–6 months	~£18	~10p	Pure quercetin from Sophora japonica — the bioavailable plant source. Key mast cell stabiliser: inhibits IgE-receptor degranulation and protects hyaluronan from tryptase degradation (critical for the CHA axis). Start with 500mg/day in MCAS; titrate to 1000mg if well-tolerated. Take before meals for best absorption.	Amazon UK
6	Hyaluronic Acid ★ NEW High-MW oral · 200mg · CHA axis support hEDSMCASPOTSMigraine	UKHealthHouse Hyaluronic Acid 200mg · 120 vegan tablets · High MW (500–700 KDA) · Natural skin, hair & joint support	1–2 tabs/day 200–400mg Morning with water	2–4 months	~£14	~12p	The newest addition based on the CHA axis research (Kirkness & Scarlata 2025). High-MW HA (500–700 KDA) binds CD44 receptors to promote fascial quiescence vs. pathological remodelling. Maintains interstitial fluid and EZ water ground substance. Oral HA shown to reach fascial and synovial tissue in RCTs. Critical for hEDS fascial repair cycle.	Amazon UK
7	Vitamin C Liposomal 1000mg · MCAS-safe form hEDSMCASMigraine	Comfort Click Liposomal Vitamin C 1000mg · 180 vegan caps (3 months) · L-Ascorbic Acid with Rosehip & Sunflower Phospholipid · Non-GMO	1 cap/day 500–1000mg With meal, split if sensitive	3–6 months	~£18	~10p	Liposomal delivery avoids GI upset common with ascorbic acid in MCAS. Essential cofactor for collagen prolyl/lysyl hydroxylases — without it collagen triple-helix formation is impaired. Also acts as a reducing agent maintaining EZ water charge in fascial tissue. Start at 500mg in MCAS and observe for 2 weeks before increasing. ⚠ MCAS: start at 250–500mg. Plain ascorbic acid tablets may increase histamine — liposomal or buffered forms preferred.	Amazon UK
8	NAC N-Acetyl Cysteine 600mg hEDSMCASMigraine	Solgar NAC NAC N-Acetyl-L-Cysteine 600mg · 60 vegan vegicaps · Gold Standard quality · Soy-free	1–2 caps/day 600–1200mg Away from meals	1–2 months	~£22	~37p	Solgar's long-established NAC 600mg is a benchmark product — clean formula, well-tolerated, consistent purity. Replenishes glutathione in fascial fibroblasts and mitochondria, reduces mast cell redox activation, and modulates glutamate (relevant for migraine threshold). Take between meals for best cysteine absorption. 💡 Better value: Nutravita NAC 600mg 150 caps (~£16 = 5-month supply, ~11p/day) for those not brand-sensitive.	Amazon UK

Phase 4 Methylation, Antioxidant Recycling & Fine-Tuning Week 12+ · Introduce one at a time · MCAS: start very low with B-complex

#	Supplement	Recommended Product	Dose / Timing	Supply	Price	Per Day	Why This Pick · Notes	Buy
9	Methylated B-Complex 5-MTHF + Methylcobalamin + P-5-P hEDSMigrainePOTS	BioCare Methyl B Complex High Potency Active B Vitamins · Methylfolate (Quatrefolic) + Methyl B12 + P-5-P B6 · 60 vegan caps · UK brand · 35+ years	1–2 caps/day Morning with food	1–2 months	~£22	~37p	BioCare is the premium UK clinical-grade choice: uses Quatrefolic (glucosamine salt of 5-MTHF — the gold standard patented methylfolate), adenosyl + methylcobalamin, and P-5-P B6. Bypasses MTHFR completely. Hypoallergenic HPMC capsule — important for MCAS. Critical for neurotransmitter synthesis, collagen repair and homocysteine clearance. ⚠ MCAS: start with ¼ capsule (open and split) for 1–2 weeks. Some individuals react to methyl donors. Try hydroxocobalamin B12 separately first if very reactive.	Amazon UK
10	R-Alpha Lipoic Acid R-ALA only · Na-RALA stabilised form POTSMigrainehEDS	Bio-Enhanced® R-Lipoic Acid Stabilised Na-RALA 245mg · 60 vegan pullulan caps · UK Made · GMP · Zero additives · Biotin included	1–2 caps/day 245–490mg Empty stomach, AM	1–2 months	~£28	~47p	Na-RALA (sodium R-lipoate) is the stabilised, highly bioavailable form of R-ALA — significantly better than racemic ALA or unstabilised R-ALA which degrades rapidly. Recycles vitamins C, E, CoQ10 and glutathione — amplifying the whole antioxidant network. Complex I cofactor. Pullulan capsule = ideal for MCAS (no gelatin, no stearates). Biotin included prevents biotin depletion at high doses. ⚠ May lower blood glucose — monitor if hypoglycaemia triggers POTS or dysautonomia episodes. Take away from food.	Amazon UK

Phase 1 (Weeks 1–4)

~£22/mo

Phase 2 add (Wks 4–8)

+£30/mo

Phase 3 add (Wks 8–12)

+£28/mo

Phase 4 add (Wk 12+)

+£25/mo

Full Stack (10 supps)

~£85–105/mo

Subscribe & Save Est.

~£72–90/mo

⚠ Important disclaimers: This is an educational reference document, not medical advice. Amazon UK prices fluctuate — always check current listings. Products change formulation; verify ingredients before purchase, especially if you have MCAS. Some links may link to search pages rather than specific listings — use the brand and product name to find the correct item. Consider Subscribe & Save (typically 5–15% discount) for long-term supplements. For MCAS: introduce one new supplement every 1–2 weeks maximum and record reactions. Always consult a knowledgeable physician before starting, especially if taking stimulants, antihistamines, anticoagulants, or immunosuppressants. Test serum levels where possible: Vitamin D (25-OH), B12, and RBC Magnesium. Prices shown are approximate as of May 2026.

The Fascia & MitochondriaSupplement Stack

The Fascia & Mitochondria
Supplement Stack